Which genes are the most important in genetic disorders?
Genetic disorders are a major concern in society, with the number of cases expected to increase to almost 2.5 million by 2030.
However, the numbers of affected individuals are far smaller than many people think.
We’ve gathered the most significant genes that impact on your health, according to research by the University of Michigan and the Johns Hopkins University School of Medicine.
Read more: What genes are key to genetic disorders, and how can you know if your genes are linked?
We’ll be profiling and analyzing the genetics of thousands of individuals, from all over the world.
Here are the top five genes most likely to impact your health.1.
Thyroid hormone: One of the most prominent factors in the development of the genetic predisposition for depression, anxiety, obsessive-compulsive disorder and many other conditions.2.
The stress hormone cortisol: Increases your risk of anxiety, depression, insomnia and other disorders.3.
Catecholamine-rich compounds in the brain, which play a key role in the regulation of emotions and cognition.4.
Biphasic dopamine receptors, which regulate dopamine and serotonin in the central nervous system.5.
Bile acids, which help regulate the body’s ability to regulate body temperature.
These are the major molecules that affect the health of the body.
The list also includes some that have been shown to be less important in some cases, such as insulin and thyroid hormones.2C-reactive protein (CRP) is a marker for inflammation.3Prostate-specific antigen (PSA) is an anti-inflammatory marker.4C-TNF-alpha is an immunomodulator.5Antibodies against prostaglandins, which are important in the maintenance of the immune system.
These markers also help us to predict the likelihood of genetic disorders.
In some cases though, we know that a gene’s contribution to a condition may be very minor.
For example, in people with familial hypercholesterolemia, there is little difference between those with and without the disorder, according the study.
But in people who have diabetes, it is not possible to tell if the disorder is caused by the gene, according its authors.4Bile acids are an important anti-bacterial and anti-fungal agent, and contribute to the prevention of urinary tract infections and colitis.5Biphasics peptide-4 is an antidiabetic agent.
This is one of the major factors in genetic conditions.
Bile acid production is controlled by the enzymes that control cholesterol and glucose levels in the blood.
The higher the levels of these enzymes, the higher the risk of developing metabolic syndrome, according researchers.6.
Lipoprotein receptor (LRP)-1 (LRR-1): LRR-2 is the main protein involved in cholesterol biosynthesis.
LRR2 regulates the expression of a family of genes that regulate LDL receptors.
This gene has been shown in other research to be associated with heart disease.7.
Serotonin transporter (SERT)-1: LRR1 regulates serotonin levels, which in turn regulates metabolism.
SERT-1 is linked to depression and anxiety.8.
TNF-α: Lrr1 and SERT2 are linked to autoimmune diseases.9.
Insulin-like growth factor-1 (IGF-1), which plays a role in metabolism and insulin secretion.10.
Glycosylated hemoglobin (GSH) is another important regulator of glucose levels.11.
The amino acid tryptophan plays a key function in glucose metabolism.12.
Antinuclear proteins are important proteins in the immune response.13.
The proteins that regulate cell growth.14.
The peptide peptidoglycan, a key regulator of growth hormone secretion.15.
The nucleotide base of histone proteins.16.
The protein protein kinase-1 which acts as an enzyme that breaks down and degrades DNA.17.
The enzyme transcription factor 1.18.
The enzymes involved in protein synthesis.19.
The gene that codes for the enzyme that binds to histone, which is involved in DNA repair and the regulation.20.
The hormone leptin.21.
A protein that regulates the rate of blood sugar regulation.22.
The hormones insulin, leptin and cortisol.
The genes that are involved in the metabolism of certain proteins.23.
The genes that mediate the actions of the endocrine hormones, such to regulate energy balance.24.
The glycoprotein-3, a protein that binds tightly to the glycoproteins of the cell membrane, to make the cell more resistant to damage.25.
The RNA polymerase complex, a molecule that binds and disassembles RNA, which allows DNA to be copied.26.
The ribosomal RNA polymerases.27.
The lipoprotein lipase.28.
The insulin-like Growth Factor-1 receptor.29. The