What do we know about cleft lip and chin?
The cleft palate is one of the most common facial malformations in males and is often caused by the fusion of two or more facial bones in the mouth, especially in people with cleft lips.
The genetic disorder occurs in one in 500,000 people.
It can be caused by mutations in genes called cleft protein-coding genes, which are responsible for producing proteins called lipoproteins.
The most common form is called clefts caused by cleft proteins, with up to a quarter of all clefts in people.
The genetic disorder is inherited from the father and causes the child to inherit a defective protein-causing protein, which makes the child vulnerable to the mutations in the genes.
The mutation causes a cleft that is normally present in the bones of the upper lip, but it can also form in the cleft in the upper jawbone, causing a protruding lip.
People with the genetic mutation are born with a large, protruding cleft on the underside of the tongue, and have a lower jawbone protruding slightly from the back of the mouth.
In some cases, the genetic disorder may affect a child for life.
There are no specific treatments for cleft, which affects up to 50 per cent of the population.
Doctors can recommend surgery to remove the clefts, but in most cases, this is only considered when a person’s cleft becomes so large it causes problems breathing or eating.
Some people with the disorder have to take medicines for months to completely heal their lips.