How genetic mosaicism may improve maternal outcomes
A new study shows that the risk of preimplanted maternal risk of miscarriage decreases as a person’s genetic matrix is modified.
The study is the first to link genetic mosaics with maternal outcomes, said lead author Dr. Jennifer A. Oleson, associate professor of obstetrics and gynecology at Brigham and Women’s Hospital and Harvard Medical School.
The new findings were published today in the journal PLOS ONE.
“There are many different kinds of mosaicism in human beings,” Olesen said.
“If we can identify these things, we can then tailor treatments based on their effectiveness.
And this is a very useful tool in treating genetic mosaices, so it’s very exciting.”
A genetic mosaic is a combination of two or more inherited genes that differ in their sequence.
The most common example of this is Xq28, which is a variant of a gene that is common in African-Americans and affects the body’s ability to secrete estrogen.
Another genetic mosaic in women is Xg28, a mutation of a protein called IGF-1 that affects muscle development.
Orosons team compared the genetic mosaickers in more than 5,000 pregnant women and mothers to see if genetic changes were associated with outcomes.
They found that maternal mosaicism is associated with a significantly lower risk of gestational diabetes and preeclampsia.
“Our results show that genetic mosaicking is not just a consequence of the mosaicism of the chromosomes, but that the genetic material is altered in the fetus and that is related to the outcomes of pregnancy,” Oroson said.
The study found that genetic changes in the mother’s DNA and maternal mosaics in the child’s DNA were associated in the womb with lower maternal risk scores.
This association was also found in the infant.
“We don’t have data on the effect of the genetic changes on the child, but we can say that there is a genetic association in the prenatal environment that affects outcomes,” Oreson said, adding that she and her colleagues are working to further explore the link.
The new study is not without controversy.
While the researchers noted that there was an association between genetic mosaicky genes and the fetus’ outcome, they did not find evidence of an association in infants born with a specific type of mosaicky gene.
“It’s important to point out that this study is very small and not the first or last to look at mosaicism,” Omesons team wrote in the study.
“It is important to emphasize that there are not many of these genetic variants, so the results should not be interpreted as evidence that genetic modification should be limited.”
For now, this study shows for the first time that genetic differences are associated in utero with an association with maternal risk.””
In addition, it is possible that there could be other factors that affect the maternal outcome as well, so future studies that look at these genes and maternal outcomes should be able to do a better job of controlling for these factors.”
For now, this study shows for the first time that genetic differences are associated in utero with an association with maternal risk.